Inborn Errors of Intermediary Metabolism in Critically Ill Mexican Newborns

Inborn Errors of Intermediary Metabolism in Critically Ill Mexican Newborns

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Inborn errors of intermediary metabolism (IEiM) are complex diseases with high clinical heterogeneity, and some patients who have severe enzyme deficiencies or are Enhancing Online Security: A Novel Machine Learning Framework for Robust Detection of Known and Unknown Malicious URLs subjected to stress (catabolism/infections) actually decompensate in the neonatal period.In this study, we performed metabolic tests on 2025 newborns in Mexico admitted to 35 neonatal intensive care units or emergency wards (NICUs/EWs) over a 6-year period, in whom a metabolic disorder was clinically suspected.Of these 2025 newborns with sickness, 11 had IEiM, revealing a prevalence of 1:184.

Clinical characteristics and outcomes of the newborns with confirmed IEiM are shown.Of these 11 patients, 4 had isolated methylmalonic acidemia, 3 had maple syrup urine disease, A Customer-Centric Approach for Recommending Products: A Case Study of Digikala 2 had urea cycle disorders, 1 had 3-hydroxy-3-methylglutaric acidemia, and 1 had isovaleric acidemia.During the first week of life (average 3 days), all of these newborns presented with impaired alertness, hypotonia, feeding difficulties, and vomiting along with metabolic acidosis and hyperammonemia.

Of the 11 newborns with IEiM, 7 died, leading to a mortality rate of 64%.In conclusion, the differential diagnosis of newborns admitted to the NICU/EW must include IEiM, requiring systematic screening of this population.